Connors agrees to escape from the institution and help Spider-Man develop a cure for the outbreak, but only if he is returned to the asylum when the crisis is resolved. Connors has been incarcerated since his Lizard rampage, and informs him of the incident. Spider-Man goes to the Beloit Psychiatric Hospital, where Dr. Spider-Man tries to fight off the cross-species in the city, but they all escape, and a giant security robot attacks him too, causing great damage to the city. Peter quickly dons his Spider-Man suit and gets the infected to quarantine, fighting off the robots in the process, but is unable to stop the cross-species from escaping into the city. However, they end up attacking Peter, as he technically is a cross-species too. Alistair unleashes his security robots, which are programmed to defend them from cross-species.

At that moment, the cross-species all react to Peter's presence and escape, infecting all of the scientists, including Smythe and Gwen, in the process. In the process, they are caught by Alistair Smythe, the new director, who explains that some scientists were indeed secretly continuing Connors' cross-species experiments by injecting animals with human DNA the cross-species carry a powerful virus and are currently being shipped to a bio-lab for disposal. Peter Parker and Gwen Stacy sneak into the restricted areas of Oscorp Industries after hours, where Gwen reveals her suspicions that they may be continuing Dr.

The game is set some months after the events of the film.

Game the amazing spiderman